Abstract
ESAT-6 is a well characterized secreted protein from Mycobacterium tuberculosis and represents the archetype of the WXG100 family of proteins. Genes encoding ESAT-6 homologues have been identified in the genome of the human pathogen Streptococcus agalactiae; one of these genes, esxA, has been cloned and the recombinant protein has been crystallized. In contrast to M. tuberculosis ESAT-6, the crystal structure of GBS1074 reveals a homo-dimeric structure similar to homologous structures from Staphylococcus aureus and Helicobacter pylori. Intriguingly, GBS1074 forms elongated fibre-like assemblies in the crystal structure. © 2010 International Union of Crystallography All rights reserved.
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Shukla, A., Pallen, M., Anthony, M., & White, S. A. (2010). The homodimeric GBS1074 from Streptococcus agalactiae. In Acta Crystallographica Section F: Structural Biology and Crystallization Communications (Vol. 66, pp. 1421–1425). https://doi.org/10.1107/S1744309110036286
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