SINGLE-NUCLEOTIDE POLYMORPHISM OF TNFSF4 (RS2205960) OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS IN BANDUNG, INDONESIA

Abstract

Objective: This study aimed to determine the genotype distribution of the TNFSF4 (Tumor Necrosis Factor Superfamily 4) gene rs2205960 in Systemic Lupus Erythematosus (SLE) patients in Bandung, West Java, Indonesia. Methods: This was a cross-sectional study; 84 genomic DNA samples were amplified, electrophoresed, then analyzed by DNA sequencing. Results: The genotype distribution of the TNFSF4 gene rs2205960 in SLE patients showed that from 84 DNA samples, 55 patients are GG (65.48%), 25 patients are GT (29.76%), and 4 patients are TT (4.76%). Conclusion: Results indicate that SLE patients in Bandung have a genotype distribution of the TNFSF4 rs2205960 gene that fulfills the Hardy-Weinberg equilibrium.