Transient contraction of mitochondria induces depolarization through the inner membrane dynamin opa1 protein

Abstract

Background: Simultaneous fluctuation of the inner membrane potential in filamentous mitochondria suggests electrical and functional connection. Results: Transient contraction of mitochondrial matrix induces depolarization through the inner membrane fusion dynamin OPA1. Conclusion: Transient mitochondrial contraction is a previously unrecognized cellular mechanism that induces depolarization. Significance: Transient morphological contraction of mitochondria represents a new mechanism regulating mitochondrial activity. ©2014 by The American Society for Biochemistry and Molecular Biology, Inc.