Modeling specific action potentials in the human atria based on a minimal single-cell model

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Abstract

We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a given amplitude, width and shape. Possible applications for supporting clinical diagnosis are pointed out.

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Richter, Y., Lind, P. G., & Maass, P. (2018). Modeling specific action potentials in the human atria based on a minimal single-cell model. PLoS ONE, 13(1). https://doi.org/10.1371/journal.pone.0190448

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