The association of C-reactive protein (CRP) gene polymorphism (+1059 G>C) with type 2 diabetes mellitus in the northwestern population of Iran

Abstract

Background: C-reactive protein (CRP) is an acute-phase protein that serves as an early biomarker for inflammation. It has been associated with an increased risk of Type 2 Diabetes Mellitus (T2DM). Objectives: This research investigated the association of +1059 G>C (rs1800947) polymorphism in the CRP gene with T2DM in the northwestern population of Iran. Methods: In this case-control study, genomic DNA was extracted from human subjects, involving 77 unrelated T2DM patients and 80 unrelated non-diabetic volunteers of a northwestern population of Iran. The CRP gene was analyzed by genotyping for +1059 G>C (rs1800947), allele-specific polymerase chain reaction (AS-PCR). Results: There were 24 (15.3%) CC genotypes, 126 (80.2%) CG genotypes, and seven (4.5%) GG genotypes. There was a significant relationship between the CG genotype of CRP +1059 G>C gene polymorphism and T2DM (P value = 0.037, 95% CI, OR = 2.385). Conclusions: The CRP was associated with T2DM in this population. The frequency of the C allele was high in the northwestern population of Iran. The CG genotype almost doubled the risk of T2DM, which has not been reported in Iran previously. However, the primary finding of this study needs subsequent validation studies.