Experimental comparison of the effects of locally administered zoledronic acid and alendronate on the rate of mandibular distraction osteogenesis in dogs

Abstract

Objective: The objective of this study was the evaluation of effects of locally administered zoledronic acid and alendronate on rate of osteogenesis in distracted mandible of dogs. Study Design: Following mandibular corticotomy, bone segments were maintained in a neutral position by distractor for 7 days then distraction was initiated at a rate of 0.5 mm twice a day for 10 days to achieve a total distraction of 10 mm, followed by a consolidation period. Animals were divided into 3 equal groups according to the injected drug (saline solution [control], zoledronic acid, alendronate). The dogs were killed 2, 6, and 10 weeks following distraction and samples were collected for radiographic examination, assessment of bone mineral density, and histopathological evaluation. Results: Radiographs and histopathological results pointed out that bone formation and maturation of experimental groups were faster than those of the control group. Conclusions: Local administration of zoledronic acid and alendronate proved to be effective in shortening the consolidation period. © 2014 Elsevier Inc. All rights reserved.