Rational design and bioimaging applications of highly selective fluorescence probes for hydrogen polysulfides

Abstract

Reactive sulfur species have received considerable attention due to their various biological functions. Among these molecules, hydrogen polysulfides (H 2 S n, n > 1) are recently suggested to be the actual signaling molecules derived from hydrogen sulfide (H 2 S). Hydrogen polysulfides may also have their own biosynthetic pathways. The research on H 2 S n is rapidly growing. However, the detection of H 2 S n is still challenging. In this work we report a H 2 S n -mediated benzodithiolone formation under mild conditions. Based on this reaction, specific fluorescent probes for H 2 S n are prepared and evaluated. The probe DSP-3 shows good selectivity and sensitivity for H 2 S n. © 2014 American Chemical Society.