Ion chromatography studies of quaternary ammonium halide solutions and the determination of pharmaceuticals

Abstract

The feasibility of using ion chromatography (IC) in solutions containing quaternary ammoniums is studied. The results establish the applicability of IC for the determination of halide ions in a pharmaceutical sample without interferences by various excipient ions. For IC measurements with suitable methodical parameters, linearity is maintained over the range of 20 to 200 mg/L and 10.0 to 250 mg/L for the chloride and bromide of quaternary ammoniums, respectively. A comparison of the anion results obtained from differential pulse voltammetry shows good agreement.