Relationship between PON1 phenotype and headache duration in migraine patients

Abstract

Aim: The available data on the activity of paraoxonase-1 (PON1) in patients suff ering from migraine without aura (MWoA) is scarce. Th e present study was conducted to fulfi ll the objective of investigating the probability of an association between PON1 phenotype distribution and headache duration in patients suff ering from MWoA. Materials and methods: Seventy-six patients who suff er from MWoA and were not experiencing attacks at the time and 65 healthy volunteers were enrolled for the purpose of evaluation in the present study. Results: Th e levels of serum paraoxonase, arylesterase activities, and lipid hydroperoxide (LOOH) were determined for these subjects. Th e results obtained revealed that no statistical diff erences existed between the group suff ering from MWoA and the control group with respect to the PON1 activity and the phenotype distribution (all values of P > 0.05), while the levels of serum LOOH were noted to be higher (P < 0.05) in the patient group. However, a signifi cant relation was found between the PON1192QR phenotype distribution and headache duration in patients suff ering from MWoA (P < 0.001). It was observed that patients with the PON1192RR (BB = homozygous high activity) polymorphism had headaches of shorter duration than patients with the PON1192QQ (AA = homozygous low activity) and PON1192QR (AB = heterozygous intermediate activity) polymorphisms. Along with these results, signifi cant negative correlations were found between the ratio of salt-stimulated paraoxonase/arylesterase and headache duration (r: -0.40, P < 0.001) in patients suff ering from MWoA in comparison to the control group. Finally, the activities of both paraoxonase and arylesterase were found to be inversely correlated with the levels of serum LOOH in the patient group [(r: -0.23, P < 0.05) and (r: -0.27, P < 0.05), respectively]. Conclusion: Th e results ascertained through the present study suggest that a signifi cant correlation exists between PON1 phenotype distribution and headache duration in patients suff ering from MWoA. Additionally, to the best of our knowledge, this is the fi rst study to evaluate the association between PON1 polymorphism and headache duration in patients with migraine. PON1 phenotype distribution will play a key role in headache duration in patients with migraine. © TÜBİTAK.