Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands

Abstract

Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1 −/− mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo .