Formulation & Evaluation of Naringin Nanoethosome by Cold Method

Abstract

Naringin is a flavonoid which shows various pharmacological effects, such as, anti-inflammatory and antioxidant,cholesterol lowering activity, free radical scavenging activity. Although naringin is easily found in citrus fruits but has lower bioavailability, biodistribution and undergoes biotransformation to naringenin. To overcome this, the main objective of this work is to formulate  nanoethosome formulation containing naringin.  The use of nanoethosomes as vesicle drug carrier having ability to increase solubility, improve biodistribution, slows the biotransformation which improves the activity of naringin for treating neurological disorder. The ethosomes were formulated by varying the variables such as concentrations of soya lecithine, polyethylene glycol, and ethanol. The formulations were evaluated  with entrapment efficiency, and particle size. Results specify that prepared nanoethosomes of naringin shows decreased particle size, better entrapment efficiency as compared to rigid ethosomes. The F4 was selected as optimized formulation which was further characterized for vesicle size determination. The F4  shows vesicles size of 145.9 nm having 83.9% entrapment efficiency. The nanoethosomes were  proved to be significantly superior in terms of amount of drug permeated into the skin, with an enhancement ratio of 3.77 when compared to rigid ethosomes. Our results suggests that nanoethosomes are an efficient carrier for improved naringin permeation & stability.