Potential Parameters in Assessment of Testicular Toxicity

Abstract

Testicular toxicity accounts for about 50% of infertility cases in men. Though, there are several approaches to detect the toxicity, the histopathological study of alterations occurred in the seminiferous tubules appear to be the most accepted, sensitive and direct marker of testicular toxicity. However, an appropriate understanding of the process of spermatogenesis and its hormonal regulation is necessary to employ the histopathological techniques for the evaluation of testicular toxicity. Further, for most accurate evaluation of testicular toxicity, other key reproductive endpoints must also be considered to know the underlying cause and nature of suppression of spermatogenesis. The present article reviews the conventional histopathological and recent biochemical and molecular techniques available as biomarkers to assess the testicular toxicity. Keywords: