Bioengineered Skin

Abstract

Bioengineered skin represents a major breakthrough in the treatment of chronic ulcers. Over the last several years considerable experience has been developed using a bilayered bioengineered skin construct (Graftskin). This type of bioengineered skin has been shown to accelerate the healing of venous ulcers, especially those that are difficult to heal and have been present for more than a year. There is now new evidence that Graftskin is also very effective in the treatment of neuropathic diabetic ulcers. In this review, we discuss bioengineered skin, its use in the treatment of chronic ulcers of the lower extremities, and possible mechanisms of action. We will also discuss how stabilization of wounds and optimal preparation of the wound bed is critical to the successful use of bioengineered skin. Finally, we will provide evidence that the results obtained with conventional therapy in the first few weeks of therapy can be predictive of ultimate wound closure, and can therefore tell us when advanced technology needs to be used.