The circadian clock ticks in organoids

Abstract

Organoids are self-organizing in vitro 3D cultures that are histologically similar to a variety of human organs. A recent study by Rosselot et al (2021) shows that mature intestinal organoids possess species-specific circadian clocks similar to their respective in vivo context, suggesting organoids as promising platforms to study circadian medicine. [ received:2021/11/08, revised:2021/11/12, accepted:2021/11/22, entrez:2021/11/23 ]