The clinical outcomes of S-1 plus cisplatin for patients with advanced gastric cancer A meta-analysis and systematic review

Abstract

Background: To evaluate the clinical outcomes of S-1 plus cisplatin (SC) for the treatment of patients with advanced gastric cancer (AGC). Methods: A systematic literature search was conducted by searching PubMed, the Cochrane Library, Embase, China Biology Medicine disc (CBMdisc), China National Knowledge Infrastructure (CNKI), and WanFang Database, for all year up to January 2017. Pooled analyses of overall survival (OS), progress-free survival rates, and adverse events were performed. Results: A total of 8 random controlled trails (RCTs) consisting of 2699 patients with AGC were selected and included in this meta-analysis. The results of our meta-analysis showed that AGC patients who treated with SC regimen receive a similar OS (HR = 1.01, 95%CI: 0.86–1.18, P = .928), PFS (HR = 0.89, 95%CI: 0.72–1.09, P = .263), and overall response rate (HR = 0.88, 95%CI: 0.70–1.11, P = .283). However, SC regimen may increase the risk of 1 to 2 grade (OR = 1.128, 95%CI: 1.075–1.184, P = .000) and 3 to 4 grade (OR = 1.24, 95%CI: 1.01–1.52, P = .039) adverse events. Conclusion: SC chemotherapy showed no difference in survival compared with 5-FU- and S-1-based other therapy, but has a higher rate of adverse events compared with other chemotherapy regimens.