Aerobic oxynitration of alkynes with tBuONO and TEMPO

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Abstract

An efficient method for stereoselective nitroaminoxylation of alkyne has been reported. The reaction enjoys a broad substrate scope, good functional group tolerance, and high yields. Synthetically useful α-nitroketones can be accessed through these products in a single step.

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Dutta, U., Maity, S., Kancherla, R., & Maiti, D. (2014). Aerobic oxynitration of alkynes with tBuONO and TEMPO. Organic Letters, 16(24), 6302–6305. https://doi.org/10.1021/ol503025n

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