Studies on chemical constituents of Sarcandra glabra

Abstract

Objective: To study antibacterial chemical constituents of Sarcandra glabra. Method: The constituents of the chloroform and EtOAc-soluble portions of the EtOH extract from the whole plant of S. glabra, which posses the antibacterial activities, were isolated and purified with column chromatography. The compounds were identified by physical and spectroscopic techniques. Result: Six compounds were isolated and identified as 4, 4′-biisofraxidin(1), esculetin(2), fraxetin(3), scoparone(4), isofraxidin (5), scopoletin(6), respectively. Conclusion: Compound 1 is a novel natural product. Compounds 2-4 were isolated from the plants of Chloranthaceae for the first time. The antibacterial activities of these six compounds were tested for the first time. Some compounds may have potential for future study and development as plant-derived oral antibacterial agents.