Desafios para a avaliação toxicológica de agrotóxicos no Brasil: desregulação endócrina e imunotoxicidade

Abstract

Intense usage of pesticides in Brazil poses a risk concerning arising of various and hazardously toxic effects such as towards to immunological and endocrine systems. Assays recommended by national and international guidelines possess limitations to perform a complete predictive evaluation of the broad spectrum of molecules and target-organs by pesticides with those properties. On the other hand interactions among immunological, endocrine and nervous systems difficult investigation of those hazards that may impact reproduction, metabolic processes, host resistance to pathogens and tumoral cells. Similar to drugs, a periodic licensing review of pesticides in Brazil must be adopted in urgent character in order to identify and ban de usage of health extremely hazardous pesticides. Although prescribed in law, licensing review demanded by health and environmental agencies is oftenly judicialized, preventing or delaying conclusion in several years. It is also upon demand a governmental policy regarding a transition from the current production model tied to agrobusiness to a production of agroecological basis.