Differentiating angiomatous meningioma from atypical meningioma using histogram analysis of apparent diffusion coefficient maps

Abstract

Background: Preoperative differentiation between angiomatous meningioma (AM) and atypical meningioma (ATM) is related to treatment planning. In this study, we explored the utility of apparent diffusion coefficient (ADC) histogram analysis in differentiating AM and ATM, and further assess the correlations between these parameters and the Ki-67 proliferation index. Methods: Thirty AM and 35 ATM patients were enrolled and their clinical and conventional magnetic resonance imaging (MRI) features were analyzed in this study. Nine ADC histogram parameters [mean, variance, skewness, and kurtosis, as well as the 1st (ADC1), 10th (ADC10), 50th (ADC50), 90th (ADC90), and 99th (ADC99) percentile of ADC] were selected and compared by independent t-test or Mann-Whitney U test. Diagnostic performance analysis was performed by receiver operating characteristic (ROC) curves. The relationship between ADC histogram parameters and the Ki-67 proliferation index was assessed by Spearman's correlation coefficient. Results: AM group showed a significantly higher mean [median (interquartile range): 124.07 (22.66) vs. 112.12 (16.04), P<0.001], ADC1 (107.50 (17.00) vs. 82.00 (20.33), P<0.001), ADC10 (mean ± standard deviation: 115.80±12.09 vs. 96.86±9.86, P<0.001), and ADC50 [124.00 (21.13) vs. 109.00 (15.17), P<0.001], compared to the ATM group. Significant correlations were identified between the mean (r=-0.428, P<0.001), ADC1 (r=-0.549, P<0.001), ADC10 (r=-0.529, P<0.001), ADC50 (r=-0.483, P<0.001), and the Ki-67 proliferation index. ROC analysis showed that the best diagnostic performance was achieved by ADC1 (AUC =0.900). Whereas, no differences were found between variance, skewness, kurtosis, ADC90, and ADC99 (P=0.067-0.787). Conclusions: AM and ATM exhibit overlapping conventional MRI features. ADC histogram analysis, especially ADC1, maybe a reliable quantitative imaging biomarker for differentiation between AM and ATM.