Drug-induced interstitial lung disease has the same degree of risk for mortality as old age in patients with lung cancer

Abstract

Background/Aim: The aim of this study was to investigate the impact of drug-induced interstitial lung disease (DILD) on the mortality of patients with lung cancer. Patients and Methods: Japanese patients with lung cancer who had received chemotherapy in Fujita Health University Hospital from January 2017 to December 2018 were enrolled in this study. The primary outcome was to identify independent factors associated with patient mortality. The secondary outcome was to identify the risk factor of DILD. Results: Four hundred and fifty-seven patients were assigned to the current study. The multivariable analysis revealed that being aged 75 years or older, small cell lung carcinoma, cancer stage IV, and DILD event were risk factors of mortality. Male sex was identified as a risk factor of DILD. Conclusion: DILD event has the same degree of risk for mortality as age 75 years or older in lung cancer patients.