GnRH-(1-5) transactivates EGFR in Ishikawa human endometrial cells via an orphan G protein-coupled receptor

43Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

The decapeptide GnRH is known for its central role in the regulation of the hypothalamo-pituitary-gonadal axis. In addition, it is also known to have local effects within peripheral tissues. The zinc metalloendopeptidase, EC 3.4.24.15 (EP24.15), can cleave GnRH at the Tyr5-Gly6 bond to form the pentapeptide, GnRH-(1-5). The central and peripheral effect of GnRH-(1-5) is different from its parent peptide, GnRH. In the current study, we examined the effect of GnRH-(1-5) on epidermal growth factor receptor (EGFR) phosphorylation and cellular migration. Using the Ishikawa cell line as a model of endometrial cancer, we demonstrate that GnRH-(1-5) stimulates epidermal growth factor release, increases the phosphorylation of EGFR (P

Cited by Powered by Scopus

270Citations
220Readers
129Citations
165Readers

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Cho-Clark, M., Larco, D. O., Semsarzadeh, N. N., Vasta, F., Mani, S. K., & John Wu, T. (2014). GnRH-(1-5) transactivates EGFR in Ishikawa human endometrial cells via an orphan G protein-coupled receptor. Molecular Endocrinology, 28(1), 80–98. https://doi.org/10.1210/me.2013-1203

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

52%

Researcher 8

38%

Professor / Associate Prof. 2

10%

Readers' Discipline

Tooltip

Medicine and Dentistry 9

38%

Biochemistry, Genetics and Molecular Bi... 7

29%

Agricultural and Biological Sciences 6

25%

Neuroscience 2

8%

Save time finding and organizing research with Mendeley

Sign up for free