Hydrogen sulfide producing enzymes in pregnancy and preeclampsia

Abstract

Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H 2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H 2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H 2S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H 2S-production and may aid in the anti-angiogenic state. © 2012 Elsevier Ltd. All rights reserved.