Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: A case-control study

Abstract

Background: The v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B gene (MAFB) has been associated with serum lipid levels in the Eurpean population, but little is known about such association in the Chinese population or in atherosclerosis-related patients. Therefore, the purpose of the present study was to assess the association of the single nucleotide polymorphisms (SNPs) in the MAFB and serum lipid levels and the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Chinese population. Methods: A total of 1,065 unrelated patients (CAD, 525 and IS, 540) and 539 healthy controls were recruited in this study. Genotypes of the MAFB rs2902940 and rs6102059 SNPs were determined by the Snapshot technology platform. Results: The rs2902940AA genotype was associated with an increased risk of CAD (adjusted OR∈=∈1.63, 95 % CI = 1.07-2.48, P∈=∈0.023) and IS (adjusted OR∈=∈1.69, 95 % CI = 1.09-2.61, P∈=∈0.017). The rs2902940GA/AA genotypes were also associated with an increased risk of CAD (adjusted OR∈=∈1.56, 95 % CI∈=∈1.04-2.32, P∈=∈0.030 for GA/AA vs. GG) and IS (adjusted OR∈=∈1.72, 95 % CI = 1.14-2.60, P∈=∈0.010 for GA/AA vs. GG). Significant interactions were observed only in those with higher body mass index (BMI), hypertension and diabetes (P∈