Common variants in FOXP1 are associated with generalized vitiligo

Abstract

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10 8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10-7). © 2010 Nature America, Inc. All rights reserved.