High classification accuracy for schizophrenia with rest and task fMRI data

Abstract

We present a novel method to extract classification features from functional magnetic resonance imaging (fMRI) data collected at rest or during the performance of a task. By combining a two-level feature identification scheme with kernel principal component analysis (KPCA) and Fisher's linear discriminant analysis (FLD), we achieve high classification rates in discriminating healthy controls from patients with schizophrenia. Experimental results using leave-one-out cross-validation show that features extracted from the default mode network (DMN) lead to a classification accuracy of over 90% in both data sets. Moreover, using a majority vote method that uses multiple features, we achieve a classification accuracy of 98% in auditory oddball (AOD) task and 93% in rest data. Several components, including DMN, temporal, and medial visual regions, are consistently present in the set of features that yield high classification accuracy. The features we have extracted thus show promise to be used as biomarkers for schizophrenia. Results also suggest that there may be different advantages to using resting fMRI data or task fMRI data. © 2012 Du, Calhoun, Li, Ma, Eichele, Kiehl, Pearlson and Adali.