Effects of inhaled fluticasone on intraocular pressure and central corneal thickness in asthmatic children without a family history of glaucoma

Abstract

Purpose: The aim of this study is to report the effects of fluticasone-inhaled corticosteroid on intraocular pressure (IOP) and central corneal thickness (CCT) of asthmatic children without a family history of glaucoma. Materials and Methods: In this prospective study, 93 children were divided into two groups: 69 asthmatic children with no family history of glaucoma who were taking inhaled fluticasone propionate 250 g daily for at least 6 months (Group 1) and 24 age-matched control subjects without asthma (Group 2). Three measurements each, of IOP and CCT, were performed with a hand-held noncontact tonometer and a noncontact specular microscope, respectively, over a 12-week period. The order of IOP and CCT measured were randomized at each visit. Between-group comparison and the relationship between CCT and IOP measurements were investigated. P < 0.05 was statistically significant. Results: The mean age was 8 2.4 years (range, 515 years) and 9 2.9 years (range, 515 years) for Groups 1 and 2, respectively (P = 0.1337). The mean IOP was 14 3.3 mmHg (range, 1024 mmHg) and 14 2.9 mmHg (range, 1122 mmHg) for Groups 1 and 2, respectively (P = 0.3626). The mean CCT was 531 30.1 m (range, 467601 m) and 519 47.0 m (range, 415589 m) for Groups 1 and 2, respectively (P = 0.1625). There was a weak but statistically significant correlation between IOP and CCT in Group 1 (Pearson′s R = 0.3580, P = 0.0025). Conclusions: Inhaled fluticasone at the regular dose used in this study over a short period (6-24 months) was not associated with a significant effect on CCT and IOP measured with noncontact devices in asthmatic children between 5 and 15 years, without a family history of glaucoma. A weak correlation between IOP and CCT values in asthmatic children did exist.