Astrogorgia sp. From Saparua, Maluku: Phytochemical Content, Antimicrobial, Antioxidant, and Cytotoxicity Properties

Abstract

Gorgonian is one of marine invertebrates that is still underexplored as a source of bioactive compounds. This study aimed to discover the biological properties of Astrogorgia sp. and its phytochemical content. A consecutive extraction method using n-hexane, ethyl acetate and methanol was conducted to obtain secondary metabolites from the sample. Antimicrobial assay was performed against ESBL E. coli, MRSA, C. albicans, and M. furfur; cytotoxicity against P388 Murine Leukaemia Cancer Cells, antioxidant was tested using DPPH method. The consecutive extraction method gave yield (%) as follows: 0.21 0.22 from n-hexane; 0.67 0.17 from acetyl acetate; and 1.20 0.50 from methanol. All fractions gave positive results on antibacterial assay against all pathogens while only gave antifungal activity against C. albicans. Methanol fraction had the highest antioxidant activity, while n-hexane fraction showed the best cytotoxicity.