Identification and characterization of an oocyte factor required for porcine nuclear reprogramming

Abstract

Background: Oocyte factors can reprogram the somatic nucleus efficiently, but these factors still need to be defined. Results: Maternal vimentin acts as a genomic protector and results in p53 down-regulation during nuclear reprogramming. Conclusion: Maternal vimentin is crucial for nuclear reprogramming. Significance: We report the first evidence of vimentin as a reprogramming factor. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.