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A new hydroxylase system in Actinomadura sp cells converting compactin to pravastatin

Journal of Industrial Microbiology and Biotechnology (1998) 20(6) 373-375
DOI: 10.1038/sj.jim.2900539
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Abstract

The hydroxylase in cell-free extracts of Actinomadura sp strain 2966 converts compactin to pravastatin. It requires NADPH as coenzyme and Mg2+ as cofactor; Mn2+ can partially replace Mg2+. In contrast with the inducible cytochrome P-450 system of Streptomyces carbophilus which catalyzes the same overall reaction, this constitutive hydroxylase is stimulated by ATP and ascorbic acid and is not inactivated by CO.

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Peng, Y., & Demain, A. L. (1998). A new hydroxylase system in Actinomadura sp cells converting compactin to pravastatin. Journal of Industrial Microbiology and Biotechnology, 20(6), 373–375. https://doi.org/10.1038/sj.jim.2900539

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