Donnan effect of protein interference in ionised calcium measurements?

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Abstract

The observation that the ionised calcium concentration is higher if measured in the original serum sample than in an ultrafiltrate is examined by means of a theoretical model. It is concluded that this difference is a predictable consequence of the Donnan equilibrium and is not a result of protein interference with the calcium-specific electrode.

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Thode, J., Fogh Andersen, N., Siggard Andersen, M., & Siggard Andersen, O. (1983). Donnan effect of protein interference in ionised calcium measurements? Annals of Clinical Biochemistry, 20(5), 271–273. https://doi.org/10.1177/000456328302000504

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