Sesquiterpenoids from the formosan soft coral sinularia leptoclados

Abstract

Chemical investigation of the soft coral Sinularia leptoclados has afforded three new sesquiterpenoids, leptocladols A (1), B (2), and 1-epi-chabrolidione A (3). The relative structures of 1-3 were determined on the basis of extensive spectroscopic analysis. The relative configuration of 1 was further confirmed by a single-crystal Xray diffraction analysis. © 2010 Pharmaceutical Society of Japan.