The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily*

Abstract

I. Introduction A. Concept of an IGFBP superfamily B. Superfamily nomenclature II. IGFBP Family A. Structure of IGFBPs B. Correlations between structure and function C. Biological functions of IGFBPs D. Genomics of IGFBPs III. Mac25 A. IGFBP-rP1 (Mac25/TAF/PSF) IV. CCN Family A. IGFBP-rP2 (CTGF) B. IGFBP-rP3 (NovH) C. IGFBP-rP4 (Cyr61) D. New members V. L56 A. IGFBP-rP5 (L56/HtrA) VI. ESM-1 A. IGFBP-rP6 (endothelial specific molecule-1) VII. Structural Relationships Within the IGFBP Superfamily A. Protein domains (modules) B. Gene structure and correlation with protein domains VIII. Functional Relationships Within the IGFBP Superfamily A. IGF binding B. Insulin binding C. IGF/insulin-independent actions IX. Evolutionary Relationships Within the IGFBP Superfamily A. N-terminal domains B. C-terminal domains C. Evolutionary models X. Summary