Tata Laksana Terkini untuk Endometriosis

Abstract

Endometriosis is a benign gynecological disease that is often found among women in reproductive age with 10% of incidence. There are many theories regarding development of endometriosis, and to date the etiopathogenesis of this disease is still controversial. Understanding the various pathogenesis of endometriosis is important for the management of endometriosis. The current management of endometriosis is still focused on the main symptoms experienced by the patients, such as pain and infertility. A number of therapeutic approaches have been developed based on the pathogenesis of endometriosis, in terms of immunological, angiogenic, hormonal, genetic, local neurogenesis, and central sensitization aspects. However, the ideal and curative treatment for endometriosis has not been found.Endometriosis merupakan penyakit ginekologi jinak yang sering dijumpai pada wanita usia produktif dengan insidensi sebesar 10%. Banyak teori mengenai terjadinya endometriosis, dan sampai saat ini, etiopatogenesis kondisi ini masih kontroversial. Memahami berbagai kemungkinan patogenesis endometriosis dapat menjadi dasar tata laksana kondisi ini. Manajemen terapi saat ini masih berdasarkan gejala utama yang dialami oleh wanita dengan endometriosis, berupa nyeri dan infertilitas. Sejumlah terapi telah dikembangkan berdasarkan patogenesis endometriosis, ditinjau dari aspek imunologi, angiogenik, hormonal, genetik, neurogenesis lokal, serta sensitisasi sentral, namun hingga saat ini terapi yang ideal dan bersifat kuratif untuk endometriosis masih belum didapatkan.