Antidiabetic and glycogenesis effects of different fractions of ethanolic extract of leaves of mangifera indica (Linn.) in normal and alloxan induced Diabetic Rats

Abstract

Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. The antihyperglycemic activity of leaves of Mangifera indica was evaluated with scientific approaches. The study was undertaken to investigate the antihyperglycemic, Oral Glucose Tolerance Test (OGTT) and glycogenesis effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of Mangifera indica. The different extracts were administered intraperitoneally as a single dose of 150 mg kg-1 b.wt. to normal, glucose induced and alloxan induced diabetic rats and found to reduce blood glucose level significantly (p<0.05). Beside these, the different fractions of Mangifera indica to the alloxan-induced diabetic rats resulted in the significant elevation of liver glycogen content which was decreased by 50.60% in diabetic control. The effects of plant extracts were compared with standard drug metformin. The phytochemical screening tests indicate the different constituents such as triterpines, alkaloids, flavonoids etc. are present in the plant which have the antidiabetic property. Thus, this investigation paves the way for plant based diabetic treatment and indicates that various fractions (Petroleum ether, ethyl acetate and chloroform) of the ethanolic extract of Mangifera indica have favorable effect in bringing down the severity of diabetes as well as increase glycogenesis activity by increasing the cellular uptake of glucose.