Formulation and Evaluation of Bisoprolol Hemifumarate Emulgel for Transdermal Drug Delivery

Abstract

The aim of this study was to formulate and evaluate bisoprolol hemifumarate emulgel using carbopol 934P with the enhancers, thymus oil and olive oil. Thymus oil and olive oil were used as permeation enhancers. The emulsion formulations were added to a base gel. The emulgel was characterized for physical characteristics, stability, skin irritation, and drug release. Formulations F1 and F5 indicated the best in-vitro drug release when compared with other preparations. Bisoprolol hemifumarate emulgel containing carbopol 934P and thymus oil or olive oil enhancers could be further developed for a topical drug delivery system.