Six-year retrospective analysis of the epidemiology and risk factors of multidrug-resistant bloodstream infections in oncology patients in Jiangxi, China

Abstract

This study addresses a critical gap in understanding the epidemiology and risk factors of multidrug-resistant bloodstream infections (MDR-BSIs) in oncology patients from a high-burden region of China. By analyzing over a thousand BSI episodes over 6 years, the study identifies the predominant bacterial species, their resistance profiles, and key clinical and procedural risk factors associated with MDR. The high rates of MDR among both Gram-negative and Gram-positive pathogens underscore the urgent need for tailored antimicrobial stewardship, infection control interventions, and individualized treatment strategies. These findings provide essential evidence for guiding empirical antibiotic choices and improving infection management protocols in cancer care settings.