Increased pentane and carbon disulfide in the breath of patients with schizophrenia

Abstract

Aims-To determine the concentrations of pentane (a marker of lipid peroxidation) and other volatile organic compounds in the breath of patients with schizophrenia. Methods-Volatile organic compounds were assayed by gas chromatography/mass spectroscopy (GCIMS) in 88 subjects-25 with acute schizophrenic psychosis, 26 with psychiatric disorders other than schizophrenia, and 37 normal volunteers. Results-The mean alveolar gradients of pentane and carbon disulfide (CS2) were significantly higher in the patients with schizophrenia than in the control groups. Conclusions-Schizophrenia may be accompanied by accelerated lipid peroxidation in cell membranes, as well as increased manufacture of CS2, a known neurotoxin.