Copper-catalyzed ambient-temperature decarboxylative annulation of isatins with amidine hydrochlorides: A facile access to 2-(1,3,5-triazin-2-yl)aniline derivatives

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Abstract

A copper-catalyzed cascade reaction using isatins and amidine hydrochlorides for the synthesis of 2-(1,3,5-triazin-2-yl)aniline derivatives has been developed. This reaction features commercially available starting materials, mild reaction conditions and good functional group tolerance.

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Jia, F. C., Xu, C., Wang, Y. W., Chen, Z. P., Chen, Y. F., & Wu, A. X. (2018). Copper-catalyzed ambient-temperature decarboxylative annulation of isatins with amidine hydrochlorides: A facile access to 2-(1,3,5-triazin-2-yl)aniline derivatives. Organic and Biomolecular Chemistry, 16(23), 4223–4226. https://doi.org/10.1039/c8ob00904j

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