WNT branches out

Abstract

WNT signalling can be mediated by β-catenin, a protein that regulates gene transcription through binding to the TCF family of transcription factors. Recent studies by William Hahn and colleagues have added to the evidence that WNT signalling through β-catenin also involves the transcriptional co-activator YES-associated protein 1 (YAP1). The authors determined which of 85 cancer cell lines had hig