TPU-0031-A and B, new antibiotics of the novobiocin group produced by Streptomyces sp. TP-A0556

Abstract

Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification. Spectroscopic analyses showed that TPU-0031-A and B were 7′-demethylnovobiocin and 5″-demethylnovobiocin, respectively. These compounds showed antibiotic activity against Gram-positive and -negative bacteria.