Highly Efficient Method for Suzuki Reactions in Aqueous Media

Abstract

Herein, we report the crystal structure and characterization of mono-6-(l-aminopropanol)-deoxy-β-cyclodextrin (Lnβ-CD). A highly efficient, in situ generated catalyst, PdCl2(Lnβ-CD), was synthesized for palladium-catalyzed cross-coupling reactions under mild reaction conditions, and the use of this catalyst in Suzuki cross-couplings was investigated. Low palladium loadings of 0.01 mol % PdCl2(Lnβ-CD) (Pd accounted for approximately 8.4% of the catalyst by mass) were found to be highly efficient for Suzuki cross-couplings in water and afforded the corresponding biaryl compounds in excellent yields. The catalyst can be recycled and reused.