Acetylation of phenols, anilines, and thiols using silica sulfuric acid under solvent-free conditions

Abstract

Silica sulfuric acid was employed as a heterogeneous catalyst for the acetylation of a variety of phenols, amines, and thiols under solvent-free conditions at room temperature. Deactivated substrates also acetylated rapidly, and the method showed the preferential selectivity for acetylation of amino group in the presence of hydroxyl groupinwhich no C-acylation was observed. © 2013 Davood Habibi et al.