Structure elucidation of fungal phenochalasins, novel inhibitors of lipid droplet formation in mouse macrophages

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Abstract

The structures of phenochalasins A and B were elucidated by spectroscopic studies including various NMR measurements. Phenochalasins A and B have the cytochalasan skeleton of the 21,23-dioxa, 17,22-dione moiety containing unique phenyl and O-methyl phenyl residues at the C-10 position, respectively.

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Tomoda, H., Namatame, I., Tabata, N., Kawaguchi, K., Si, S., & Omura, S. (1999). Structure elucidation of fungal phenochalasins, novel inhibitors of lipid droplet formation in mouse macrophages. Journal of Antibiotics, 52(10), 857–861. https://doi.org/10.7164/antibiotics.52.857

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