Correlation Between Cut-off Level of Tissue Transglutaminase Antibody and Marsh Classification

Abstract

InTRoDUCTIon Celiac disease (CD) is a gluten related autoimmune disease occurring in ge-netically susceptible patients. Patients with CD show a wide variety of clinical manifestations. 1 The diagnosis of CD is based on clinical findings, serological tests, and histopathological evaluations. 2,3 The first paraclinical step in the diag-nosis of CD is serological assessment. There are several serological antibodies for early detection. 1,4 There is no reliable cut-off level of serology in adult CD by now. Initial evaluation of CD is based on detecting tissue transglutaminase immunoglobulin (IgA) antibodies. 2-6 There are several studies suggesting that