A role for Efg1p in Candida albicans interactions with extracellular matrices

Abstract

Candida albicans interactions with extracellular matrices extracellular matrices represent hallmarks of invasive candidiasis. We have assessed the role of Efg1p, a key transcriptional regulator, in the interactions between C. albicans and extracellular matrices. Wild-type C. albicans cells were able to bind and subsequently penetrate the extracellular matrices layer, whereas the Δefg1/Δefg1 mutant strain showed a drastically reduced ability to interact with extracellular matrices. Results indicate that, besides its control of morphogenesis, Efg1p also regulates C. albicans interactions with extracellular matrices. Proteomic analyses indicated that expression of 30 surface-associated proteins is affected in the Δefg1/Δefg1 mutant, some of which may be involved in adherence to extracellular matrices. © 2006 Federation of European Microbiological Societies Published by Blackwell Publishing Ltd. All rights reserved.