A review on pharmacological activities and traditional uses of Glycyrrhiza glabra (licorice)

Abstract

In recent years, there has been a notable increase in consumer interest in natural medicines and principles, driven by the perception of their safety. Concurrently, industries are showing a growing demand for plants traditionally used in medicine, seeking to incorporate them into various products like foods, nutraceuticals, cosmetics, and pharmaceuticals. Glycyrrhiza glabra Linn., has been esteemed for its medicinal properties since ancient times. It contains several phytocompounds, including glycyrrhizin, 18 β‐glycyrrhetinic acid, glabrin A and B, and isoflavones, which exhibit diverse pharmacological activities such as antibacterial, anti‐inflammatory, antiviral, antioxidant, and antidiabetic effects. While some toxicological studies have raised concerns, this review aims to comprehensively examine the composition and biological activities of G. glabra. The goal is to explore its therapeutic potential and address future challenges, with the aim of utilizing it in the formulation of new products to enhance human well-being.