Abstract
Bicarbonate-responsive "soluble" adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.
Author supplied keywords
Cite
CITATION STYLE
Zippin, J. H., Farrell, J., Huron, D., Kamenetsky, M., Hess, K. C., Fischman, D. A., … Buck, J. (2004). Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain. Journal of Cell Biology, 164(4), 527–534. https://doi.org/10.1083/jcb.200311119
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
