Alternative 1-13C glucose infusion protocols for clinical 13C MRS examinations of the brain

32Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Clinical utility of 13C MRS is limited by cost and long examination times. Three 1-13C glucose infusion protocols-a high-dose i.v., low-dose i.v., and oral administration of 1-13C glucose-were compared on a GE 1.5T MR scanner. Resolution and sensitivity were sufficient to identify 13C glucose (1α and 1β), glutamate (C1-C4), glutamine (C1-C4), aspartate (C2 and C3), lactate, alanine, and bicarbonate in brain spectra. The three protocols were efficacious, as measured by cerebral enrichment of 1-13C glucose (62%, 42%, and 38%) and its principal metabolite, 4-13C glutamate (13%, 11%, and 16%), respectively. Intravenous infusion of 1-13C glucose 0.23 g/kg body weight (low dose) provides equivalent information at one third the cost of previous regimes. © 2001 Wiley-Liss, Inc.

Cite

CITATION STYLE

APA

Moreno, A., Blüml, S., Hwang, J. H., & Ross, B. D. (2001). Alternative 1-13C glucose infusion protocols for clinical 13C MRS examinations of the brain. Magnetic Resonance in Medicine, 46(1), 39–48. https://doi.org/10.1002/mrm.1158

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free