Protection against ischemia/reperfusion injury by high-density lipoprotein and its components

Abstract

Apolipoprotein D is expressed in many tissues after injury, such as reperfusion injury after myocardial infarction. Antioxidant activity of apolipoprotein D appears to confer cardioprotective properties after myocardial infarction in a mouse model of severe rapidly progressing coronary atherosclerosis and in a mouse model of ischemia/reperfusion injury. © 2013 American Heart Association, Inc.