The effect of hyaluronidase injection on the vitreous humour of the rabbit

Abstract

1. The hyaluronic acid in the vitreous humour is disaggregated by hyaluronidase injection and remains so for at least a month. After this time aggregated hyaluronic acid is found, showing that hyaluronic acid can be produced in or secreted into the vitreous humour during life. 2. Injection of rabbit testis hyaluronidase preparations into the vitreous humour of the rabbit caused a prolonged inflammatory reaction, noticeable within two hours in the aqueous humour and after 24 hours in the vitreous humour. 3. The nitrogen contents of both vitreous and aqueous humours are increased after hyaluronidase injection.